System biology-guided chemical proteomics to discover protein targets of monoethylhexyl phthalate in regulating cell cycle

• Main Authors: Xu, Tengfei, Chen, Liyan, Lim, Yan Ting, Zhao, Haoduo, Chen, Hongjin, Chen, Ming Wei, Huan, Tao, Huang, Yichao, Sobota, Radoslaw Mikolaj, Fang, Mingliang
• Other Authors: School of Civil and Environmental Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Environmental engineering; Monoethylhexyl Phthalate; Proteomics
• Online Access: https://hdl.handle.net/10356/159777
• Institution: Nanyang Technological University

Chemical proteomics methods have been used as effective tools to identify novel protein targets for small molecules. These methods have great potential to be applied as environmental toxicants to figure out their mode of action. However, these assays usually generate dozens of possible targets, maki...