Activation of autophagy ameliorates age-related neurogenesis decline and neurodysfunction in adult mice

• Main Authors: Yang, Na, Liu, Xueqin, Niu, Xiaojie, Wang, Xiaoqiang, Jiang, Rong, Yuan, Na, Wang, Jianrong, Zhang, Chengwu, Lim, Kah-Leong, Lu, Li
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Autophagy; Neural Progenitor Cell
• Online Access: https://hdl.handle.net/10356/159784
• Institution: Nanyang Technological University

Adult neurogenesis is the ongoing generation of functional new neurons from neural progenitor cells (NPCs) in the mammalian brain. However, this process declines with aging, which is implicated in the recession of brain function and neurodegeneration. Understanding the mechanism of adult neurogenesi...