Nanocapsules produced by nanoprecipitation of designed suckerin-silk fusion proteins

Nanocapsules produced by nanoprecipitation of designed suckerin-silk fusion proteins

Herein, we report on the precise design of a modular fusion protein amenable to the construction of nanocapsules by nanoprecipitation. The central squid suckerin-derived peptide block provides structural stability, whereas both termini from spider silk fibroins make the protein highly soluble at phy...

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Bibliographic Details
Main Authors: Ramos, Ricardo, Koh, Kenrick, Gabryelczyk, Bartosz, Chai, Luxiao, Kanagavel, Deepankumar, Yan, Xibo, Ganachaud, François, Miserez, Ali, Bernard, Julien
Other Authors: School of Materials Science and Engineering
Format: Article
Language:English
Published: 2022
Subjects:
Engineering::Materials
Spider Silk
Nanocarriers
Online Access:https://hdl.handle.net/10356/159959
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Institution: Nanyang Technological University
Language: English
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Summary:Herein, we report on the precise design of a modular fusion protein amenable to the construction of nanocapsules by nanoprecipitation. The central squid suckerin-derived peptide block provides structural stability, whereas both termini from spider silk fibroins make the protein highly soluble at physiological pH, a critical requirement for the nanoprecipitation process. With this design, nanocapsules consisting of fusion protein shells and oily cores with sizes in the range of 190-250 nm are built in a straightforward manner.

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