Copper-catalyzed meta-selective arylation of phenol derivatives: an easy access to m-aryl phenols

• Main Authors: Maraswami, Manikantha, Hirao, Hajime, Loh, Teck-Peng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Carbamates; Phenols
• Online Access: https://hdl.handle.net/10356/159979
• Institution: Nanyang Technological University

Achieving selective meta-functionalization of phenols is a significant challenge. Accessing such compounds generally needs elevated temperature or incorporation of complex templates. Here, we report a general approach to achieve meta-arylated phenols with a simple and common directing group. This coppercatalyzed protocol proceeds with complete meta-selectivity and tolerates a variety of functional groups in both coupling partners. Computational studies have revealed that the reaction proceeded via a Heck-like pathway.