Self-assembly of dendritic DNA into a hydrogel: application in three-dimensional cell culture

• Main Authors: Wu, Jingyuan, Liyarita, Bella Rosa, Zhu, Haishuang, Liu, Ming, Hu, Xiao, Shao, Fangwei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Materials; DNA Hydrogel; Cell Spheroids
• Online Access: https://hdl.handle.net/10356/160082
• Institution: Nanyang Technological University

With inherent biocompatibility, biodegradability, and unique programmability, hydrogels with a DNA framework show great potential in three-dimensional (3D) cell culture. Here, a DNA hydrogel was assembled by a dendritic DNA with four branches. The hydrogel showed tunable mechanical strength and reve...