Rationalisation of antifungal properties of α-helical pore-forming peptide, mastoparan B

• Main Authors: Lim, Edward Jianyang, Goh, Eunice Tze Leng, Tram, Nhan Dai Thien, Periayah, Mercy Halleluyah, Ee, Rachel Pui Lai, Barkham, Timothy Mark Sebastian, Poh, Zhi Sheng, Verma, Navin Kumar, Lakshminarayanan, Rajamani
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Antifungal Peptides; Drug Resistance
• Online Access: https://hdl.handle.net/10356/160143
• Institution: Nanyang Technological University

The high mortality associated with invasive fungal infections, narrow spectrum of available antifungals, and increasing evolution of antifungal resistance necessitate the development of alternative therapies. Host defense peptides are regarded as the first line of defense against microbial invasion...