Insights into potential causes of vascular hyperpermeability in dengue

• Main Authors: Teo, Andrew, Chua, Caroline Lin Lin, Chia, Po Ying, Yeo, Tsin Wen
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Dengue; Blood Vessel Permeability
• Online Access: https://hdl.handle.net/10356/160185
• Institution: Nanyang Technological University

Dengue is a mosquito-borne disease caused by dengue virus (DENV), where four serotypes can infect humans. Most DENV infections are self-resolving, but in some individuals, severe dengue characterised by a sudden increase in haematocrit, rapid decrease in platelet counts, and vascular leakage is a complication [1,2]. In severe dengue, a major pathogenic mechanism is a transient increase in vascular permeability resulting in severe plasma leakage (herein referred to vascular hyperpermeability) leading to hypotension, circulatory collapse, and organ dysfunction [1]. The precise mechanism in DENV-associated vascular hyperpermeability is unclear, and several hypotheses including antibody-dependent enhancement (ADE) and “cytokine storm” have been proposed. In ADE, suboptimal DENV neutralising antibodies against a heterologous serotype (in secondary infection) promotes DENV uptake into immunological cells, increasing infection and viral replication that can exacerbate the immune response [3]. Similarly, infected monocytes release excessive amounts of proinflammatory cytokines and, if dysregulated, can lead to “cytokine storm” [4]. In this article, we present current understandings on the potential causes of dengue-associated vascular hyperpermeability, which is a consequence of complex interactions between the virus and the host endothelium immune response.