Deep eutectic solvent as green solvent in extraction of biological macromolecules: a review
Greater awareness of environmental sustainability has driven many industries to transition from using synthetic organic solvents to greener solvents in their manufacturing. Deep eutectic solvents (DESs) have emerged as a highly promising category of green solvents with well-demonstrated and wide-ran...
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sg-ntu-dr.10356-1602032023-12-29T06:46:26Z Deep eutectic solvent as green solvent in extraction of biological macromolecules: a review Ling, Jordy Kim Ung Hadinoto, Kunn School of Chemical and Biomedical Engineering Engineering::Chemical engineering Carbohydrates Deep Eutectic Solvents Greater awareness of environmental sustainability has driven many industries to transition from using synthetic organic solvents to greener solvents in their manufacturing. Deep eutectic solvents (DESs) have emerged as a highly promising category of green solvents with well-demonstrated and wide-ranging applications, including their use as a solvent in extraction of small-molecule bioactive compounds for food and pharmaceutical applications. The use of DES as an extraction solvent of biological macromolecules, on the other hand, has not been as extensively studied. Thereby, the feasibility of employing DES for biomacromolecule extraction has not been well elucidated. To bridge this gap, this review provides an overview of DES with an emphasis on its unique physicochemical properties that make it an attractive green solvent (e.g., non-toxicity, biodegradability, ease of preparation, renewable, tailorable properties). Recent advances in DES extraction of three classes of biomacromolecules-i.e., proteins, carbohydrates, and lipids-were discussed and future research needs were identified. The importance of DES's properties-particularly its viscosity, polarity, molar ratio of DES components, and water addition-on the DES extraction's performance were discussed. Not unlike the findings from DES extraction of bioactive small molecules, DES extraction of biomacromolecules was concluded to be generally superior to extraction using synthetic organic solvents. Ministry of Education (MOE) Published version The authors would like to acknowledge the research funding from Singapore’s Ministry of Education Academic Research Fund Tier 1 (MOE AcRF Tier 1 RG82/20). 2022-07-15T05:37:02Z 2022-07-15T05:37:02Z 2022 Journal Article Ling, J. K. U. & Hadinoto, K. (2022). Deep eutectic solvent as green solvent in extraction of biological macromolecules: a review. International Journal of Molecular Sciences, 23(6), 3381-. https://dx.doi.org/10.3390/ijms23063381 1661-6596 https://hdl.handle.net/10356/160203 10.3390/ijms23063381 35328803 2-s2.0-85126589335 6 23 3381 en RG82/20 International Journal of Molecular Sciences © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). application/pdf |
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Engineering::Chemical engineering Carbohydrates Deep Eutectic Solvents Ling, Jordy Kim Ung Hadinoto, Kunn Deep eutectic solvent as green solvent in extraction of biological macromolecules: a review |
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Greater awareness of environmental sustainability has driven many industries to transition from using synthetic organic solvents to greener solvents in their manufacturing. Deep eutectic solvents (DESs) have emerged as a highly promising category of green solvents with well-demonstrated and wide-ranging applications, including their use as a solvent in extraction of small-molecule bioactive compounds for food and pharmaceutical applications. The use of DES as an extraction solvent of biological macromolecules, on the other hand, has not been as extensively studied. Thereby, the feasibility of employing DES for biomacromolecule extraction has not been well elucidated. To bridge this gap, this review provides an overview of DES with an emphasis on its unique physicochemical properties that make it an attractive green solvent (e.g., non-toxicity, biodegradability, ease of preparation, renewable, tailorable properties). Recent advances in DES extraction of three classes of biomacromolecules-i.e., proteins, carbohydrates, and lipids-were discussed and future research needs were identified. The importance of DES's properties-particularly its viscosity, polarity, molar ratio of DES components, and water addition-on the DES extraction's performance were discussed. Not unlike the findings from DES extraction of bioactive small molecules, DES extraction of biomacromolecules was concluded to be generally superior to extraction using synthetic organic solvents. |
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School of Chemical and Biomedical Engineering |
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School of Chemical and Biomedical Engineering Ling, Jordy Kim Ung Hadinoto, Kunn |
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Article |
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Ling, Jordy Kim Ung Hadinoto, Kunn |
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Ling, Jordy Kim Ung |
title |
Deep eutectic solvent as green solvent in extraction of biological macromolecules: a review |
title_short |
Deep eutectic solvent as green solvent in extraction of biological macromolecules: a review |
title_full |
Deep eutectic solvent as green solvent in extraction of biological macromolecules: a review |
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Deep eutectic solvent as green solvent in extraction of biological macromolecules: a review |
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Deep eutectic solvent as green solvent in extraction of biological macromolecules: a review |
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deep eutectic solvent as green solvent in extraction of biological macromolecules: a review |
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2022 |
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https://hdl.handle.net/10356/160203 |
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