Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion

• Main Authors: Monzo, Pascale, Crestani, Michele, Chong, Yuk Kien, Ghisleni, Andrea, Hennig, Katharina, Li, Qingsen, Kakogiannos, Nikolaos, Giannotta, Monica, Richichi, Cristina, Dini, Tania, Dejana, Elisabetta, Maiuri, Paolo, Balland, Martial, Sheetz, Michael P., Pelicci, Giuliana, Ang, Beng Ti, Tang, Carol, Gauthier, Nils C.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Glioma-Cell Migration; Brain-Tumor
• Online Access: https://hdl.handle.net/10356/160323
• Institution: Nanyang Technological University

Glioblastoma are heterogeneous tumors composed of highly invasive and highly proliferative clones. Heterogeneity in invasiveness could emerge from discrete biophysical properties linked to specific molecular expression. We identified clones of patient-derived glioma propagating cells that were eithe...