Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy

Polypoidal choroidal vasculopathy (PCV), a subtype of age-related macular degeneration (AMD), is a global leading cause of vision loss in older populations. Distinct from typical AMD, PCV is characterized by polyp-like dilatation of blood vessels and turbulent blood flow in the choroid of the eye. G...

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Main Authors:	Wu, Kan Xing, Yeo, Natalie Jia Ying, Ng, Chun Yi, Chioh, Florence Wen Jing, Fan, Qiao, Tian, Xianfeng, Yang, Binxia, Narayanan, Gunaseelan, Tay, Hui Min, Hou, Han Wei, Dunn, Norris Ray, Su, Xinyi, Cheung, Gemmy Chui Ming, Cheung, Christine
Other Authors:	Lee Kong Chian School of Medicine (LKCMedicine)
Format:	Article
Language:	English
Published:	2022
Subjects:	Science::Medicine Endothelial Dysfunction Glycocalyx
Online Access:	https://hdl.handle.net/10356/160330
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Institution:	Nanyang Technological University
Language:	English

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spelling	sg-ntu-dr.10356-1603302023-02-28T17:12:19Z Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy Wu, Kan Xing Yeo, Natalie Jia Ying Ng, Chun Yi Chioh, Florence Wen Jing Fan, Qiao Tian, Xianfeng Yang, Binxia Narayanan, Gunaseelan Tay, Hui Min Hou, Han Wei Dunn, Norris Ray Su, Xinyi Cheung, Gemmy Chui Ming Cheung, Christine Lee Kong Chian School of Medicine (LKCMedicine) School of Biological Sciences School of Mechanical and Aerospace Engineering Institute of Medical Biology, ASTAR Institute of Molecular and Cell Biology, ASTAR Science::Medicine Endothelial Dysfunction Glycocalyx Polypoidal choroidal vasculopathy (PCV), a subtype of age-related macular degeneration (AMD), is a global leading cause of vision loss in older populations. Distinct from typical AMD, PCV is characterized by polyp-like dilatation of blood vessels and turbulent blood flow in the choroid of the eye. Gold standard anti-vascular endothelial growth factor (anti-VEGF) therapy often fails to regress polypoidal lesions in patients. Current animal models have also been hampered by their inability to recapitulate such vascular lesions. These underscore the need to identify VEGF-independent pathways in PCV pathogenesis. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) National Research Foundation (NRF) Published version The team from Nanyang Technological University Singapore was funded by the Nanyang Assistant Professorship and Academic Research Fund Tier 2 grant (MOE2018-T2-1-042) from the Ministry of Education, Singapore. N.J.Y.Y is supported by the Nanyang President’s Graduate Scholarship. C.C. and C.M.G.C. were funded by the SERI-IMCB Program in Retinal Angiogenic Diseases (SIPRAD) grant (SPF2014/002) from Agency for Science, Technology and Research, Singapore. X.S. is funded by a grant (CRP21-2018-00103) from the National Research Foundation (Singapore). 2022-07-19T06:42:45Z 2022-07-19T06:42:45Z 2022 Journal Article Wu, K. X., Yeo, N. J. Y., Ng, C. Y., Chioh, F. W. J., Fan, Q., Tian, X., Yang, B., Narayanan, G., Tay, H. M., Hou, H. W., Dunn, N. R., Su, X., Cheung, G. C. M. & Cheung, C. (2022). Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy. BMC Biology, 20(1), 47-. https://dx.doi.org/10.1186/s12915-022-01244-z 1741-7007 https://hdl.handle.net/10356/160330 10.1186/s12915-022-01244-z 35164755 2-s2.0-85124680333 1 20 47 en MOE2018-T2-1-042 SPF2014/002 CRP21-2018-00103 BMC Biology © 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	Science::Medicine Endothelial Dysfunction Glycocalyx
spellingShingle	Science::Medicine Endothelial Dysfunction Glycocalyx Wu, Kan Xing Yeo, Natalie Jia Ying Ng, Chun Yi Chioh, Florence Wen Jing Fan, Qiao Tian, Xianfeng Yang, Binxia Narayanan, Gunaseelan Tay, Hui Min Hou, Han Wei Dunn, Norris Ray Su, Xinyi Cheung, Gemmy Chui Ming Cheung, Christine Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy
description	Polypoidal choroidal vasculopathy (PCV), a subtype of age-related macular degeneration (AMD), is a global leading cause of vision loss in older populations. Distinct from typical AMD, PCV is characterized by polyp-like dilatation of blood vessels and turbulent blood flow in the choroid of the eye. Gold standard anti-vascular endothelial growth factor (anti-VEGF) therapy often fails to regress polypoidal lesions in patients. Current animal models have also been hampered by their inability to recapitulate such vascular lesions. These underscore the need to identify VEGF-independent pathways in PCV pathogenesis.
author2	Lee Kong Chian School of Medicine (LKCMedicine)
author_facet	Lee Kong Chian School of Medicine (LKCMedicine) Wu, Kan Xing Yeo, Natalie Jia Ying Ng, Chun Yi Chioh, Florence Wen Jing Fan, Qiao Tian, Xianfeng Yang, Binxia Narayanan, Gunaseelan Tay, Hui Min Hou, Han Wei Dunn, Norris Ray Su, Xinyi Cheung, Gemmy Chui Ming Cheung, Christine
format	Article
author	Wu, Kan Xing Yeo, Natalie Jia Ying Ng, Chun Yi Chioh, Florence Wen Jing Fan, Qiao Tian, Xianfeng Yang, Binxia Narayanan, Gunaseelan Tay, Hui Min Hou, Han Wei Dunn, Norris Ray Su, Xinyi Cheung, Gemmy Chui Ming Cheung, Christine
author_sort	Wu, Kan Xing
title	Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy
title_short	Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy
title_full	Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy
title_fullStr	Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy
title_full_unstemmed	Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy
title_sort	hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy
publishDate	2022
url	https://hdl.handle.net/10356/160330
_version_	1759855942499827712

Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy

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