Lewy body-like inclusions in human midbrain organoids carrying glucocerebrosidase and α-synuclein mutations

• Main Authors: Jo, Junghyun, Yang, Lin, Tran, Hoang-Dai, Yu, Weonjin, Sun, Alfred Xuyang, Chang, Ya Yin, Jung, Byung Chul, Lee, Seung-Jae, Saw, Tzuen Yih, Xiao, Bin, Khoo, Audrey Tze Ting, Yaw, Lai-Ping, Xie, Jessica Jiaxin, Lokman, Hidayat, Ong, Wei-Yi, Lim, Grace Gui Yin, Lim, Kah-Leong, Tan, Eng-King, Ng, Huck-Hui, Je, Hyunsoo Shawn
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Alpha-Synuclein; Embryonic Stem Cells
• Online Access: https://hdl.handle.net/10356/160355
• Institution: Nanyang Technological University

Objective: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parkinson disease, with the particular aim of recapitulat...