A novel human arterial wall-on-a-chip to study endothelial inflammation and vascular smooth muscle cell migration in early atherosclerosis

• Main Authors: Su, Chengxun, Menon, Nishanth Venugopal, Xu, Xiaohan, Teo, Yu Rong, Cao, Huan, Dalan, Rinkoo, Tay, Chor Yong, Hou, Han Wei
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Extracellular-Matrix; Phenotypic Properties
• Online Access: https://hdl.handle.net/10356/160379
• Institution: Nanyang Technological University

Mechanistic understanding of atherosclerosis is largely hampered by the lack of a suitable in vitro human arterial model that recapitulates the arterial wall structure, and the interplay between different cell types and the surrounding extracellular matrix (ECM). This work introduces a novel microfl...