Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis

• Main Authors: Teo, Yi Juan, Ng, See Liang, Mak, Keng Wai, Setiagani, Yolanda Aphrilia, Chen, Qi, Nair, Sajith Kumar, Sheng, Jianpeng, Ruedl, Christiane
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Candidiasis; Acute Disease
• Online Access: https://hdl.handle.net/10356/160608
• Institution: Nanyang Technological University

Disseminated candidiasis remains as the most common hospital-acquired bloodstream fungal infection with up to 40% mortality rate despite the advancement of medical and hygienic practices. While it is well established that this infection heavily relies on the innate immune response for host survival,...