WBP2 inhibits microRNA biogenesis via interaction with the microprocessor complex

• Main Authors: Tabatabaeian, Hossein, Lim, Shen Kiat, Chu, Tinghine, Seah, Sock Hong, Lim, Yoon Pin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Breast Neoplasms; Carcinogenesis
• Online Access: https://hdl.handle.net/10356/160675
• Institution: Nanyang Technological University

WBP2 is an emerging oncoprotein with diverse functions in breast tumorigenesis via regulating Wnt, epidermal growth factor receptor, estrogen receptor, and Hippo. Recently, evidence shows that WBP2 is tightly regulated by the components of the miRNA biogenesis machinery such as DGCR8 and Dicer via p...