N-WASP attenuates cell proliferation and migration through ERK2-dependent enhanced expression of TXNIP

• Main Authors: Chung, Yat Joong, Salvi, Amrita, Kalailingam, Pazhanichamy, Alnawaz, Myra, Tan, Suat Hoon, Pan, Jiun Yit, Tan, Nguan Soon, Thanabalu, Thirumaran
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Cell Adhesion; Actin Cytoskeleton
• Online Access: https://hdl.handle.net/10356/160717
• Institution: Nanyang Technological University

Neural Wiskott-Aldrich Syndrome Protein (N-WASP) regulates actin cytoskeleton remodeling. It has been known that reduced N-WASP expression in breast and colorectal cancers is associated with poor prognosis. Here, we found reduced N-WASP expression in squamous cell carcinoma (SCC) patient samples. Th...