Towards malaria field diagnosis based on surface-enhanced Raman scattering with on-chip sample preparation and near-analyte nanoparticle synthesis

• Main Authors: Yuen, Clement, Gao, Xiaohong, Yong, James Jia Ming, Prakash, Prem, Shobana, Chalapathy Raja, Kaushalya, Perera Adhikarige Taniya, Luo, Yuemei, Bai, Yanru, Yang, Chun, Preiser, Peter Rainer, Liu, Quan
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Hemozoin Detection; Raman Spectroscopy
• Online Access: https://hdl.handle.net/10356/160773
• Institution: Nanyang Technological University

We report a chip based on surface-enhanced Raman scattering (SERS) developed towards malaria field diagnosis. Only a mixture of 10-μl water and 10-μl blood is required as the sample input to the chip. Water is the only lysing agent to hemolyze blood cells while keeping the malaria biomarkers, hemozo...