A pilot study of estrogen receptor (ER) expression in pancreatic ductal adenocarcinoma (PDAC)
Background: Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic neoplasm with 5-year survival as low as 6%. It is therefore imperative to explore potential treatment avenues to improve survival in these groups of patients. Anti-estrogenic hormone therapy (AEHT) is well-tolerated an...
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sg-ntu-dr.10356-1608192023-03-05T16:52:29Z A pilot study of estrogen receptor (ER) expression in pancreatic ductal adenocarcinoma (PDAC) Chan, Kai Siang Ho, Bernard Chi Shern Shelat, Vishal G. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Estrogen Receptor Hormonal Therapy Background: Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic neoplasm with 5-year survival as low as 6%. It is therefore imperative to explore potential treatment avenues to improve survival in these groups of patients. Anti-estrogenic hormone therapy (AEHT) is well-tolerated and has been used in estrogen receptor (ER) subgroups of breast cancer. ER is a type of sex hormone receptor which have been reported to be expressed inconsistently in pancreatic cancer. This study aims to identify the presence of ER in PDAC specimens to guide potential use of AEHT in the management of unresectable PDAC. Methods: This is a retrospective case control study of 10 patients (5 males, 5 females) who underwent pancreatic resections for PDAC from 2011 to 2012. Sections of the post-operative specimens were prepared and sent for ER staining. Pancreatic tissue specimens that were analysed included (I) ductal epithelial cells; (II) acinar cells; (III) islet cells; (IV) intralobular stromal cells; and (V) adenocarcinoma cells. Results: Intralobular stromal cells were positively stained for ER in 7/10 (70%) of the cases, but were of weak intensity and patchy in distribution. Islet cells (<1%) stained for ER in 3/10 (30%) of the cases. Ductal epithelial cells, acinar cells and adenocarcinoma cells stained negative for ER in all of the cases. Conclusions: This pilot study did not detect the presence of ER expression in PDAC. ER expression in intralobular stromal and islet cells which was previously unreported, were noted in our study. The role of AEHT in pancreatic cancer remains uncertain and does not appear to be of value at present. National Research Foundation (NRF) Published version This study is funded by the National Research Foundation Scholarship Grant. 2022-08-03T04:58:08Z 2022-08-03T04:58:08Z 2021 Journal Article Chan, K. S., Ho, B. C. S. & Shelat, V. G. (2021). A pilot study of estrogen receptor (ER) expression in pancreatic ductal adenocarcinoma (PDAC). Translational Gastroenterology and Hepatology, 6. https://dx.doi.org/10.21037/TGH.2020.02.16 2415-1289 https://hdl.handle.net/10356/160819 10.21037/TGH.2020.02.16 2-s2.0-85102411631 6 en Translational Gastroenterology and Hepatology © Translational Gastroenterology and Hepatology. All rights reserved. This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. application/pdf |
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Science::Medicine Estrogen Receptor Hormonal Therapy Chan, Kai Siang Ho, Bernard Chi Shern Shelat, Vishal G. A pilot study of estrogen receptor (ER) expression in pancreatic ductal adenocarcinoma (PDAC) |
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Background: Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic neoplasm with 5-year survival as low as 6%. It is therefore imperative to explore potential treatment avenues to improve survival in these groups of patients. Anti-estrogenic hormone therapy (AEHT) is well-tolerated and has been used in estrogen receptor (ER) subgroups of breast cancer. ER is a type of sex hormone receptor which have been reported to be expressed inconsistently in pancreatic cancer. This study aims to identify the presence of ER in PDAC specimens to guide potential use of AEHT in the management of unresectable PDAC. Methods: This is a retrospective case control study of 10 patients (5 males, 5 females) who underwent pancreatic resections for PDAC from 2011 to 2012. Sections of the post-operative specimens were prepared and sent for ER staining. Pancreatic tissue specimens that were analysed included (I) ductal epithelial cells; (II) acinar cells; (III) islet cells; (IV) intralobular stromal cells; and (V) adenocarcinoma cells. Results: Intralobular stromal cells were positively stained for ER in 7/10 (70%) of the cases, but were of weak intensity and patchy in distribution. Islet cells (<1%) stained for ER in 3/10 (30%) of the cases. Ductal epithelial cells, acinar cells and adenocarcinoma cells stained negative for ER in all of the cases. Conclusions: This pilot study did not detect the presence of ER expression in PDAC. ER expression in intralobular stromal and islet cells which was previously unreported, were noted in our study. The role of AEHT in pancreatic cancer remains uncertain and does not appear to be of value at present. |
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Lee Kong Chian School of Medicine (LKCMedicine) |
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Lee Kong Chian School of Medicine (LKCMedicine) Chan, Kai Siang Ho, Bernard Chi Shern Shelat, Vishal G. |
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Article |
author |
Chan, Kai Siang Ho, Bernard Chi Shern Shelat, Vishal G. |
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Chan, Kai Siang |
title |
A pilot study of estrogen receptor (ER) expression in pancreatic ductal adenocarcinoma (PDAC) |
title_short |
A pilot study of estrogen receptor (ER) expression in pancreatic ductal adenocarcinoma (PDAC) |
title_full |
A pilot study of estrogen receptor (ER) expression in pancreatic ductal adenocarcinoma (PDAC) |
title_fullStr |
A pilot study of estrogen receptor (ER) expression in pancreatic ductal adenocarcinoma (PDAC) |
title_full_unstemmed |
A pilot study of estrogen receptor (ER) expression in pancreatic ductal adenocarcinoma (PDAC) |
title_sort |
pilot study of estrogen receptor (er) expression in pancreatic ductal adenocarcinoma (pdac) |
publishDate |
2022 |
url |
https://hdl.handle.net/10356/160819 |
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1759855341108985856 |