Cryo-EM structure of the entire FtsH-HflKC AAA protease complex

• Main Authors: Qiao, Zhu, Yokoyama, Tatsuhiko, Yan, Xin-Fu, Beh, Ing Tsyr, Shi, Jian, Basak, Sandip, Akiyama, Yoshinori, Gao, Yong-Gui
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; AAA Protease; Protein Quality Control
• Online Access: https://hdl.handle.net/10356/160820
• Institution: Nanyang Technological University

The membrane-bound AAA protease FtsH is the key player controlling protein quality in bacteria. Two single-pass membrane proteins, HflK and HflC, interact with FtsH to modulate its proteolytic activity. Here, we present structure of the entire FtsH-HflKC complex, comprising 12 copies of both HflK an...