Cryo-EM structure of the entire FtsH-HflKC AAA protease complex

• المؤلفون الرئيسيون: Qiao, Zhu, Yokoyama, Tatsuhiko, Yan, Xin-Fu, Beh, Ing Tsyr, Shi, Jian, Basak, Sandip, Akiyama, Yoshinori, Gao, Yong-Gui
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Biological sciences; AAA Protease; Protein Quality Control
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/160820

The membrane-bound AAA protease FtsH is the key player controlling protein quality in bacteria. Two single-pass membrane proteins, HflK and HflC, interact with FtsH to modulate its proteolytic activity. Here, we present structure of the entire FtsH-HflKC complex, comprising 12 copies of both HflK an...