Leucine-rich α-2-glycoprotein 1 suppresses endothelial cell activation through ADAM10-mediated shedding of TNF-α receptor

• Main Authors: Pang, Kuin Tian, Ghim, Mean, Liu, Chenghao, Tay, Hui Min, Fhu, Chee Wai, Chia, Rui Ning, Qiu, Beiying, Sarathchandra, Padmini, Chester, Adrian H., Yacoub, Magdi H., Wilkinson, Fiona L., Weston, Ria, Warboys, Christina M., Hou, Han Wei, Weinberg, Peter D., Wang, Xiaomeng
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; TNFR1 Shedding; Endothelial Activation
• Online Access: https://hdl.handle.net/10356/160829
• Institution: Nanyang Technological University

Elevated serum concentrations of leucine-rich α-2-glycoprotein (LRG1) have been reported in patients with inflammatory, autoimmune, and cardiovascular diseases. This study aims to investigate the role of LRG1 in endothelial activation. LRG1 in endothelial cells (ECs) of arteries and serum of patient...