Cutibacterium acnes: much ado about maybe nothing much

Cutibacterium acnes (also known as Propionibacterium acnes) has long been implicated in the pathogenesis of acne, inspiring both therapeutic and personal care approaches aiming to control the disease by controlling the bacterium. The purported association has made people with acne feel dirty and led...

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Main Authors: van Steensel, Maurice A. M., Chong, Goh Boon
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/160840
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-1608402022-08-03T06:49:36Z Cutibacterium acnes: much ado about maybe nothing much van Steensel, Maurice A. M. Chong, Goh Boon Lee Kong Chian School of Medicine (LKCMedicine) Skin Research Institute of Singapore, A*STAR Science::Medicine Acne Comedo Cutibacterium acnes (also known as Propionibacterium acnes) has long been implicated in the pathogenesis of acne, inspiring both therapeutic and personal care approaches aiming to control the disease by controlling the bacterium. The purported association has made people with acne feel dirty and led to the-at times excessive-use of cleansers, antiseptics and antibiotics for the condition. However, recent evidence seems to weaken the case for C. acnes' involvement. New genetics and molecular biology findings strongly suggest that abnormal differentiation of sebaceous progenitor cells causes comedones, the primary lesions in acne. Comodegenesis is initiated by androgens and is unlikely to be triggered by C. acnes, which probably doesn't affect sebaceous differentiation. Is there still a place for it in this understanding of acne? It is necessary to critically address this question because it has consequences for treatment. Antibiotic use for acne noticeably contributes to microbial drug resistance, which we can ill afford. In this Viewpoint, we explore if and how C. acnes (still) fits into the developing view on acne. We also briefly discuss the implications for therapy in the light of antibiotic resistance and the need for more targeted therapies. Agency for Science, Technology and Research (A*STAR) National Research Foundation (NRF) SMART Innovation Centre MvS is funded by the Biomedical Research Council (BMRC) A*STAR, BMRC-A*STAR-EDB IAF-PP for the Skin Research Institute of Singapore (H17/01/a0/004) and the Acne and Sebaceous Gland Program (H17/01/a0/008), and a SMART Innovation Grant. GBC is supported by the Innovation Centre and Antimicrobial Resistance IRG of the Singapore-MIT Alliance for Research and Technology Centre, supported by the National Research Foundation, Prime Minister’s Office, Singapore under its Campus for Research Excellence and Technological Enterprise (CREATE) Program. He is also supported by a SMART Innovation Grant. 2022-08-03T06:49:36Z 2022-08-03T06:49:36Z 2021 Journal Article van Steensel, M. A. M. & Chong, G. B. (2021). Cutibacterium acnes: much ado about maybe nothing much. Experimental Dermatology, 30(10), 1471-1476. https://dx.doi.org/10.1111/exd.14394 0906-6705 https://hdl.handle.net/10356/160840 10.1111/exd.14394 34009698 2-s2.0-85107404586 10 30 1471 1476 en H17/01/a0/004 H17/01/a0/008 Experimental Dermatology © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
Acne
Comedo
spellingShingle Science::Medicine
Acne
Comedo
van Steensel, Maurice A. M.
Chong, Goh Boon
Cutibacterium acnes: much ado about maybe nothing much
description Cutibacterium acnes (also known as Propionibacterium acnes) has long been implicated in the pathogenesis of acne, inspiring both therapeutic and personal care approaches aiming to control the disease by controlling the bacterium. The purported association has made people with acne feel dirty and led to the-at times excessive-use of cleansers, antiseptics and antibiotics for the condition. However, recent evidence seems to weaken the case for C. acnes' involvement. New genetics and molecular biology findings strongly suggest that abnormal differentiation of sebaceous progenitor cells causes comedones, the primary lesions in acne. Comodegenesis is initiated by androgens and is unlikely to be triggered by C. acnes, which probably doesn't affect sebaceous differentiation. Is there still a place for it in this understanding of acne? It is necessary to critically address this question because it has consequences for treatment. Antibiotic use for acne noticeably contributes to microbial drug resistance, which we can ill afford. In this Viewpoint, we explore if and how C. acnes (still) fits into the developing view on acne. We also briefly discuss the implications for therapy in the light of antibiotic resistance and the need for more targeted therapies.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
van Steensel, Maurice A. M.
Chong, Goh Boon
format Article
author van Steensel, Maurice A. M.
Chong, Goh Boon
author_sort van Steensel, Maurice A. M.
title Cutibacterium acnes: much ado about maybe nothing much
title_short Cutibacterium acnes: much ado about maybe nothing much
title_full Cutibacterium acnes: much ado about maybe nothing much
title_fullStr Cutibacterium acnes: much ado about maybe nothing much
title_full_unstemmed Cutibacterium acnes: much ado about maybe nothing much
title_sort cutibacterium acnes: much ado about maybe nothing much
publishDate 2022
url https://hdl.handle.net/10356/160840
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