Cutibacterium acnes: much ado about maybe nothing much
Cutibacterium acnes (also known as Propionibacterium acnes) has long been implicated in the pathogenesis of acne, inspiring both therapeutic and personal care approaches aiming to control the disease by controlling the bacterium. The purported association has made people with acne feel dirty and led...
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sg-ntu-dr.10356-1608402022-08-03T06:49:36Z Cutibacterium acnes: much ado about maybe nothing much van Steensel, Maurice A. M. Chong, Goh Boon Lee Kong Chian School of Medicine (LKCMedicine) Skin Research Institute of Singapore, A*STAR Science::Medicine Acne Comedo Cutibacterium acnes (also known as Propionibacterium acnes) has long been implicated in the pathogenesis of acne, inspiring both therapeutic and personal care approaches aiming to control the disease by controlling the bacterium. The purported association has made people with acne feel dirty and led to the-at times excessive-use of cleansers, antiseptics and antibiotics for the condition. However, recent evidence seems to weaken the case for C. acnes' involvement. New genetics and molecular biology findings strongly suggest that abnormal differentiation of sebaceous progenitor cells causes comedones, the primary lesions in acne. Comodegenesis is initiated by androgens and is unlikely to be triggered by C. acnes, which probably doesn't affect sebaceous differentiation. Is there still a place for it in this understanding of acne? It is necessary to critically address this question because it has consequences for treatment. Antibiotic use for acne noticeably contributes to microbial drug resistance, which we can ill afford. In this Viewpoint, we explore if and how C. acnes (still) fits into the developing view on acne. We also briefly discuss the implications for therapy in the light of antibiotic resistance and the need for more targeted therapies. Agency for Science, Technology and Research (A*STAR) National Research Foundation (NRF) SMART Innovation Centre MvS is funded by the Biomedical Research Council (BMRC) A*STAR, BMRC-A*STAR-EDB IAF-PP for the Skin Research Institute of Singapore (H17/01/a0/004) and the Acne and Sebaceous Gland Program (H17/01/a0/008), and a SMART Innovation Grant. GBC is supported by the Innovation Centre and Antimicrobial Resistance IRG of the Singapore-MIT Alliance for Research and Technology Centre, supported by the National Research Foundation, Prime Minister’s Office, Singapore under its Campus for Research Excellence and Technological Enterprise (CREATE) Program. He is also supported by a SMART Innovation Grant. 2022-08-03T06:49:36Z 2022-08-03T06:49:36Z 2021 Journal Article van Steensel, M. A. M. & Chong, G. B. (2021). Cutibacterium acnes: much ado about maybe nothing much. Experimental Dermatology, 30(10), 1471-1476. https://dx.doi.org/10.1111/exd.14394 0906-6705 https://hdl.handle.net/10356/160840 10.1111/exd.14394 34009698 2-s2.0-85107404586 10 30 1471 1476 en H17/01/a0/004 H17/01/a0/008 Experimental Dermatology © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved. |
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Science::Medicine Acne Comedo van Steensel, Maurice A. M. Chong, Goh Boon Cutibacterium acnes: much ado about maybe nothing much |
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Cutibacterium acnes (also known as Propionibacterium acnes) has long been implicated in the pathogenesis of acne, inspiring both therapeutic and personal care approaches aiming to control the disease by controlling the bacterium. The purported association has made people with acne feel dirty and led to the-at times excessive-use of cleansers, antiseptics and antibiotics for the condition. However, recent evidence seems to weaken the case for C. acnes' involvement. New genetics and molecular biology findings strongly suggest that abnormal differentiation of sebaceous progenitor cells causes comedones, the primary lesions in acne. Comodegenesis is initiated by androgens and is unlikely to be triggered by C. acnes, which probably doesn't affect sebaceous differentiation. Is there still a place for it in this understanding of acne? It is necessary to critically address this question because it has consequences for treatment. Antibiotic use for acne noticeably contributes to microbial drug resistance, which we can ill afford. In this Viewpoint, we explore if and how C. acnes (still) fits into the developing view on acne. We also briefly discuss the implications for therapy in the light of antibiotic resistance and the need for more targeted therapies. |
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Lee Kong Chian School of Medicine (LKCMedicine) |
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Lee Kong Chian School of Medicine (LKCMedicine) van Steensel, Maurice A. M. Chong, Goh Boon |
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Article |
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van Steensel, Maurice A. M. Chong, Goh Boon |
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van Steensel, Maurice A. M. |
title |
Cutibacterium acnes: much ado about maybe nothing much |
title_short |
Cutibacterium acnes: much ado about maybe nothing much |
title_full |
Cutibacterium acnes: much ado about maybe nothing much |
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Cutibacterium acnes: much ado about maybe nothing much |
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Cutibacterium acnes: much ado about maybe nothing much |
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cutibacterium acnes: much ado about maybe nothing much |
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2022 |
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https://hdl.handle.net/10356/160840 |
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1743119518741299200 |