Stereoselective synthesis of trifluoromethyl-substituted 2H-furan-amines from enaminones

• Main Authors: Liang, Xiaoyu, Guo, Pan, Yang, Wenjie, Li, Meng, Jiang, Chengzhou, Sun, Wangbin, Loh, Teck-Peng, Jiang, Yaojia
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Science::Chemistry; Regioselective Synthesis; Annulation
• 在線閱讀: https://hdl.handle.net/10356/160880
• 機構: Nanyang Technological University

A straightforward strategy for synthesis of highly functionalized trifluoromethyl 2H-furans is described. The copper catalyzed method relies on a cascade cyclic reaction between enaminones and N-tosylhydrazones. This method allows the synthesis of 2-amino-3-trifluoromethyl-substituted 2H-furan deriv...