The ratio of nicotinic acid to nicotinamide as a microbial biomarker for assessing cell therapy product sterility

• المؤلفون الرئيسيون: Huang, Jiayi, Cui, Liang, Natarajan, Meenubharathi, Barone, Paul W., Wolfrum, Jacqueline M., Lee, Yie Hou, Rice, Scott A., Springs, Stacy L.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Biological sciences; Cell Therapy Products; Sterility Test
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/160886

Controlling microbial risks in cell therapy products (CTPs) is important for product safety. Here, we identified the nicotinic acid (NA) to nicotinamide (NAM) ratio as a biomarker that detects a broad spectrum of microbial contaminants in cell cultures. We separately added six different bacterial sp...