The ratio of nicotinic acid to nicotinamide as a microbial biomarker for assessing cell therapy product sterility

• Main Authors: Huang, Jiayi, Cui, Liang, Natarajan, Meenubharathi, Barone, Paul W., Wolfrum, Jacqueline M., Lee, Yie Hou, Rice, Scott A., Springs, Stacy L.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Cell Therapy Products; Sterility Test
• Online Access: https://hdl.handle.net/10356/160886
• Institution: Nanyang Technological University

Controlling microbial risks in cell therapy products (CTPs) is important for product safety. Here, we identified the nicotinic acid (NA) to nicotinamide (NAM) ratio as a biomarker that detects a broad spectrum of microbial contaminants in cell cultures. We separately added six different bacterial sp...