Crystal structure and functional analysis of mycobacterial erythromycin resistance methyltransferase Erm38 reveals its RNA-binding site

• Main Authors: Goh, Boon Chong, Xiang, Xinyu, Lescar, Julien, Dedon, Peter C.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Antibiotic Resistance; RNA-Binding Protein
• Online Access: https://hdl.handle.net/10356/161111
• Institution: Nanyang Technological University

Erythromycin resistance methyltransferases (Erms) confer resistance to macrolide, lincosamide, and streptogramin antibiotics in Gram-positive bacteria and mycobacteria. Although structural information for ErmAM, ErmC, and ErmE exists from Gram-positive bacteria, little is known about the Erms in myc...