Age-related bone loss is associated with FGF21 but not IGFBP1 in healthy adults

• Main Authors: Lee, Shuen Yee, Fam, Kai Deng, Chia, Kar Ling, Yap, Margaret M. C., Goh, Jorming, Yeo, Kwee Poo, Yap, Eric Peng Huat, Chotirmall, Sanjay Haresh, Lim, Chin Leong
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Bone Mineral Density; Bone Turnover
• Online Access: https://hdl.handle.net/10356/161157
• Institution: Nanyang Technological University

Bone fragility increases with age. The fibroblast growth factor 21 (FGF21)–insulin-like growth factor binding protein 1 (IGFBP1) axis regulates bone loss in animals. However, the role of FGF21 in mediating age-associated bone fragility in humans remains unknown. The purpose of this study was to expl...