Tricking enzymes in living cells: a mechanism-based strategy for design of DNA topoisomerase biosensors

• Main Authors: Ba, Sai, Gao, Guangpeng, Li, Tianhu, Zhang, Hao
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; DNA Topoisomerases; Cancer Diagnosis
• Online Access: https://hdl.handle.net/10356/161365
• Institution: Nanyang Technological University

Most activity-based molecular probes are designed to target enzymes that catalyze the breaking of chemical bonds and the conversion of a unimolecular substrate into bimolecular products. However, DNA topoisomerases are a class of enzymes that alter DNA topology without producing any molecular segmen...