Functional and molecular characterisation of heart failure progression in mice and the role of myosin regulatory light chains in the recovery of cardiac muscle function

• Main Authors: Markandran, Kasturi, Yu, Haiyang, Song, Weihua, Lam, Do Thuy Uyen Ha, Madathummal, Mufeeda Changaramvally, Ferenczi, Michael Alan
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Cardiac Regulatory Light Chain; Enzymes
• Online Access: https://hdl.handle.net/10356/161395
• Institution: Nanyang Technological University

Heart failure (HF) as a result of myocardial infarction (MI) is a major cause of fatality worldwide. However, the cause of cardiac dysfunction succeeding MI has not been elucidated at a sarcomeric level. Thus, studying the alterations within the sarcomere is necessary to gain insights on the fundame...