Review: F-actin remodelling during plant signal transduction via biomolecular assembly

During signal transduction, multivalent interactions establish dynamic molecular connectivities that propagate molecular cascades throughout the entire signaling pathway. Such multivalent interactions include the initial activation, cascade signal transduction, and the amplification and assembly of...

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Main Authors: Ma, Zhiming, Miao, Yansong
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/161401
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1614012022-08-30T08:47:39Z Review: F-actin remodelling during plant signal transduction via biomolecular assembly Ma, Zhiming Miao, Yansong School of Biological Sciences Science::Biological sciences Actin Phase Separation During signal transduction, multivalent interactions establish dynamic molecular connectivities that propagate molecular cascades throughout the entire signaling pathway. Such multivalent interactions include the initial activation, cascade signal transduction, and the amplification and assembly of structural machinery. For example, plants rapidly remodel the actin cytoskeleton during signal transduction by perceiving a wide range of mechanical and chemical cues from developmental and defense pathways. Actin treadmilling is stepwise-regulated by interactions between actin and actin-binding proteins (ABPs). Emerging evidence shows that intrinsically disordered regions (IDRs) enable flexible and promiscuous interactions that serve as the functional hub for generating cellular interactomes underlying various signaling events. Though IDRs are present in a majority of ABPs, few of the functional roles of IDR in the interaction and functions of ABPs have been defined. The distinct features of IDRs create diverse and dynamic molecular interactions that introduce a new paradigm to our understanding of the structure-function relationships for actin assembly. In this review, we will create a snapshot of recent advances in IDR-mediated plant actin remodeling and discuss future research directions in studying the complexity of actin assembly via multifaceted biomolecular assembly during signal transduction. Ministry of Education (MOE) Nanyang Technological University This study was supported by NTU startup grant (M4081533) and the Ministry of Education Tier 3 (MOE2019-T3-1-012) to Y.M. in Singapore. 2022-08-30T08:47:39Z 2022-08-30T08:47:39Z 2020 Journal Article Ma, Z. & Miao, Y. (2020). Review: F-actin remodelling during plant signal transduction via biomolecular assembly. Plant Science, 301, 110663-. https://dx.doi.org/10.1016/j.plantsci.2020.110663 0168-9452 https://hdl.handle.net/10356/161401 10.1016/j.plantsci.2020.110663 33218630 2-s2.0-85090839596 301 110663 en M4081533 MOE2019-T3-1-012 Plant Science © 2020 Elsevier B.V. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Biological sciences
Actin
Phase Separation
spellingShingle Science::Biological sciences
Actin
Phase Separation
Ma, Zhiming
Miao, Yansong
Review: F-actin remodelling during plant signal transduction via biomolecular assembly
description During signal transduction, multivalent interactions establish dynamic molecular connectivities that propagate molecular cascades throughout the entire signaling pathway. Such multivalent interactions include the initial activation, cascade signal transduction, and the amplification and assembly of structural machinery. For example, plants rapidly remodel the actin cytoskeleton during signal transduction by perceiving a wide range of mechanical and chemical cues from developmental and defense pathways. Actin treadmilling is stepwise-regulated by interactions between actin and actin-binding proteins (ABPs). Emerging evidence shows that intrinsically disordered regions (IDRs) enable flexible and promiscuous interactions that serve as the functional hub for generating cellular interactomes underlying various signaling events. Though IDRs are present in a majority of ABPs, few of the functional roles of IDR in the interaction and functions of ABPs have been defined. The distinct features of IDRs create diverse and dynamic molecular interactions that introduce a new paradigm to our understanding of the structure-function relationships for actin assembly. In this review, we will create a snapshot of recent advances in IDR-mediated plant actin remodeling and discuss future research directions in studying the complexity of actin assembly via multifaceted biomolecular assembly during signal transduction.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Ma, Zhiming
Miao, Yansong
format Article
author Ma, Zhiming
Miao, Yansong
author_sort Ma, Zhiming
title Review: F-actin remodelling during plant signal transduction via biomolecular assembly
title_short Review: F-actin remodelling during plant signal transduction via biomolecular assembly
title_full Review: F-actin remodelling during plant signal transduction via biomolecular assembly
title_fullStr Review: F-actin remodelling during plant signal transduction via biomolecular assembly
title_full_unstemmed Review: F-actin remodelling during plant signal transduction via biomolecular assembly
title_sort review: f-actin remodelling during plant signal transduction via biomolecular assembly
publishDate 2022
url https://hdl.handle.net/10356/161401
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