Implementation of universal newborn screening for severe combined immunodeficiency in Singapore while continuing routine Bacille-Calmette-Guerin vaccination given at birth

• Main Authors: Chan, Bianca Su-Wan, Zhong, Youjia, Lim, James Soon Chuan, Poh, Sherry, Teh, Kai Liang, Soh, Jian Yi, Chong, Chia Yin, Thoon, Koh Cheng, Seng, Michaela, Tan, Ee Shien, Arkachaisri, Thaschawee, Liew, Woei Kang
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Severe Combined Immunodeficiency; Newborn Screening
• Online Access: https://hdl.handle.net/10356/161474
• Institution: Nanyang Technological University

Introduction: Severe Combined Immunodeficiency (SCID) is generally fatal if untreated; it predisposes to severe infections, including disseminated Bacille-Calmette-Guerin (BCG) disease from BCG vaccination at birth. However, delaying BCG vaccination can be detrimental to the population in tuberculos...