Analysis of archaic human haplotypes suggests that 5hmC acts as an epigenetic guide for NCO recombination

• Main Authors: Lee, Bernett, Cyrill, Samantha Leeanne, Lee, Wendy, Melchiotti, Rossella, Andiappan, Anand Kumar, Poidinger, Michael, Rötzschke, Olaf
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Meiotic Recombination; Epigenetic Inheritance
• Online Access: https://hdl.handle.net/10356/161495
• Institution: Nanyang Technological University

Background: Non-crossover (NCO) refers to a mechanism of homologous recombination in which short tracks of DNA are copied between homologue chromatids. The allelic changes are typically restricted to one or few SNPs, which potentially allow for the gradual adaptation and maturation of haplotypes. It...