Analysis of archaic human haplotypes suggests that 5hmC acts as an epigenetic guide for NCO recombination

• المؤلفون الرئيسيون: Lee, Bernett, Cyrill, Samantha Leeanne, Lee, Wendy, Melchiotti, Rossella, Andiappan, Anand Kumar, Poidinger, Michael, Rötzschke, Olaf
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Medicine; Meiotic Recombination; Epigenetic Inheritance
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/161495
• المؤسسة: Nanyang Technological University

Background: Non-crossover (NCO) refers to a mechanism of homologous recombination in which short tracks of DNA are copied between homologue chromatids. The allelic changes are typically restricted to one or few SNPs, which potentially allow for the gradual adaptation and maturation of haplotypes. It...