Insights into the mechanism, structure and potential as drug target of the mycobacterial bd-type terminal oxidase

• المؤلف الرئيسي: Ekaterina, Sviriaeva
• مؤلفون آخرون: Kevin Pethe
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2022
• الموضوعات: Science::Biological sciences::Microbiology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/161580
• المؤسسة: Nanyang Technological University

Mycobacterium tuberculosis, the causative agent of tuberculosis, possesses two terminal oxidases, the cytochrome bcc:aa3 (cyt-bcc:aa3) and the cytochrome bd (cyt-bd). While the cyt-bcc:aa3 is the target of the drug candidate Q203, the cyt-bd remains poorly understood. This work aimed to study the st...