Targeting the menaquinol binding loop of mycobacterial cytochrome bd oxidase

• Main Authors: Harikishore, Amaravadhi, Chong, Sherilyn Shi Min, Ragunathan, Priya, Bates, Roderick Wayland, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences::Biochemistry; Science::Biological sciences::Molecular biology; Tuberculosis; Mycobacteria
• Online Access: https://hdl.handle.net/10356/139176
• Institution: Nanyang Technological University

Mycobacteria have shown enormous resilience to survive and persist by remodeling and altering metabolic requirements. Under stringent conditions or exposure to drugs, mycobacteria have adapted to rescue themselves by shutting down their major metabolic activity and elevate certain survival factor le...