Targeting mycobacterial F-ATP synthase C-terminal α subunit interaction motif on rotary subunit γ

• Main Authors: Harikishore, Amaravadhi, Wong, Chui-Fann, Ragunathan, Priya, Litty, Dennis, Müller, Volker, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences::Biochemistry; Tuberculosis; Mycobacteria; F-ATP synthase; Bioenergetics; Inhibitor; Pharmacophore
• Online Access: https://hdl.handle.net/10356/155649
• Institution: Nanyang Technological University

Mycobacteria regulate their energy (ATP) levels to sustain their survival even in stringent living conditions. Recent studies have shown that mycobacteria not only slow down their respiratory rate but also block ATP hydrolysis of the F-ATP synthase (α3 :β3 :γ:δ:ε:a:b:b’:c9 ) to maintain ATP hom...