Atomic solution structure of Mycobacterium abscessus F-ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor

Atomic solution structure of Mycobacterium abscessus F-ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor

Mycobacterium abscessus (Mab) is a nontuberculous mycobacterium of increasing clinical relevance. The rapidly growing opportunistic pathogen is intrinsically multi-drug-resistant and causes difficult-to-cure lung disease. Adenosine triphosphate, generated by the essential F1 FO ATP synthase, is the...

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Bibliographic Details
Main Authors: Shin, Joon, Harikishore, Amaravadhi, Wong, Chui Fann, Ragunathan, Priya, Dick, Thomas, Grüber, Gerhard
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences::Biophysics
Mycobacteria
F-ATP Synthase
Bioenergetics
Oxidative Phosphorylation
ε Enzyme Inhibitor
NMR Spectroscopy
Online Access:https://hdl.handle.net/10356/162167
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/162167

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