Cryo-EM structure of the Mycobacterium abscessus F1-ATPase

• Main Authors: Wong, Chui Fann, Leow, Chen Yen, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences::Biochemistry; Science::Biological sciences::Biophysics; ATP Synthase; Bioenergetics; Electron Microscopy; Infectious Diseases; Mycobacterium; Non-Tuberculous Mycobacteria
• Online Access: https://hdl.handle.net/10356/169214
• Institution: Nanyang Technological University

The cases of lung disease caused by non-tuberculous mycobacterium Mycobacterium abscessus (Mab) are increasing and not reliably curable. Repurposing of anti-tuberculosis inhibitors brought the oxidative phosphorylation pathway with its final product ATP, formed by the essential F1FO-ATP synthase (su...