A systematic assessment of mycobacterial F1-ATPase subunit ϵ’s role in latent ATPase hydrolysis

• Main Authors: Wong, Chui-Fann, Lau, Aik-Meng, Harikishore, Amaravadhi, Saw, Wuan-Geok, Shin, Joon, Ragunathan, Priya, Bhushan, Shashi, Ngan, So-Fong Cam, Sze, Siu Kwan, Bates, Roderick Wayland, Dick, Thomas, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences::Biochemistry; Bioenergetics; F-ATP Synthase
• Online Access: https://hdl.handle.net/10356/149231
• Institution: Nanyang Technological University

In contrast to most bacteria, the mycobacterial F1FO-ATP synthase (α3:β3:γ:δ:ϵ:a:b:b’:c9) does not perform ATP hydrolysis-driven proton translocation. Although subunits α, γ and ϵ of the catalytic F1-ATPase component α3:β3:γ:ϵ have all been implicated in the suppression of the enzyme’s ATPase ac...