Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery

by Harikishore, Amaravadhi, Mathiyazakan, Vikneswaran, Pethe, Kevin, Grüber, Gerhard
Published 2023

Cryo-electron microscopy structure of the Mycobacterium tuberculosis cytochrome bcc:aa₃ supercomplex and a novel inhibitor targeting subunit cytochrome cI

by Mathiyazakan, Vikneswaran, Wong, Chui Fann, Harikishore, Amaravadhi, Pethe, Kevin, Grüber, Gerhard
Published 2023

Deciphering the role of ion channels in early defense signaling against herbivorous insects

by Gandhi, Akanksha, Kariyat, Rupesh, Harikishore, Amaravadhi, Ayati, Marzieh, Bhunia, Anirban, Sahoo, Nirakar
Published 2021

Combination of pharmacophore hypothesis and molecular docking to identify novel inhibitors of HCV NS5B polymerase

by Harikishore, Amaravadhi, Li, Enlin, Lee, Jia Jun, Cho, Nam-Joon, Yoon, Ho Sup
Published 2015

Targeting the menaquinol binding loop of mycobacterial cytochrome bd oxidase

by Harikishore, Amaravadhi, Chong, Sherilyn Shi Min, Ragunathan, Priya, Bates, Roderick Wayland, Grüber, Gerhard
Published 2020

Targeting mycobacterial F-ATP synthase C-terminal α subunit interaction motif on rotary subunit γ

by Harikishore, Amaravadhi, Wong, Chui-Fann, Ragunathan, Priya, Litty, Dennis, Müller, Volker, Grüber, Gerhard
Published 2022

Atomic solution structure of Mycobacterium abscessus F-ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor

by Shin, Joon, Harikishore, Amaravadhi, Wong, Chui Fann, Ragunathan, Priya, Dick, Thomas, Grüber, Gerhard
Published 2022

14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway

by Mukherjee, Soumita, Roy, Somesh, Mukherjee, Shruti, Harikishore, Amaravadhi, Bhunia, Anirban, Mandal, Atin K.
Published 2024

Solution structure of FK506-binding protein 12 from Aedes aegypti

by Chakraborty, Goutam, Shin, Joon, Nguyen, Quoc Toan, Harikishore, Amaravadhi, Baek, Kwanghee, Yoon, Ho Sup
Published 2013

Mutational analysis of mycobacterial F‑ATP synthase subunit δ leads to a potent δ enzyme inhibitor

by Harikishore, Amaravadhi, Saw, Wuan-Geok, Ragunathan, Priya, Litty, Dennnis, Dick, Thomas, Müller, Volker, Grüber, Gerhard
Published 2022

The flavonoid myricetin reduces nocturnal melatonin levels in the blood through the inhibition of serotonin N-acetyltransferase

by Shin, Jae-Cheon, Jung, Hoe-Yune, Harikishore, Amaravadhi, Kwon, Oh-Deog, Yoon, Ho Sup, Kim, Kyong-Tai, Choi, Bo-Hwa
Published 2013

Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide

by Alag, Reema, Bharatham, Nagakumar, Dong, Aiping, Hills, Tanya, Harikishore, Amaravadhi, Widjaja, Anissa Anindya, Shochat, Susana Geifman, Hui, Raymond, Yoon, Ho Sup
Published 2012

Antiviral activity against Middle East Respiratory Syndrome coronavirus by Montelukast, an anti-asthma drug

by Gan, Hanjie Jonathan, Harikishore, Amaravadhi, Lee, Jihye, Jeon, Sangeun, Rajan, Sreekanth, Chen, Ming Wei, Neo, Jun Long, Kim, Seungtaek, Yoon, Ho Sup
Published 2022

Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents

by Hegde, Pooja V., Aragaw, Wassihun W., Cole, Malcolm S., Jachak, Gorakhnath, Ragunathan, Priya, Sharma, Sachin, Harikishore, Amaravadhi, Grüber, Gerhard, Dick, Thomas, Aldrich, Courtney C.
Published 2023

Structural and mechanistic insights into Mycobacterium abscessus as-partate decarboxylase PanD and a pyrazinoic acid-derived inhibitor

by Saw, Wuan Geok, Leow, Chen Yen, Harikishore, Amaravadhi, Shin, Joon, Cole, Malcolm S., Aragaw, Wassihun Wedajo, Ragunathan, Priya, Hegde, Pooja, Aldrich, Courtney C., Dick, Thomas, Grüber, Gerhard
Published 2022

Luteolin suppresses cancer cell proliferation by targeting vaccinia-related kinase 1

by Kim, Ye Seul, Kim, Seong-Hoon, Shin, Joon, Harikishore, Amaravadhi, Lim, Jong-Kwan, Jung, Youngseob, Lyu, Ha-Na, Baek, Nam-In, Choi, Kwan Yong, Yoon, Ho Sup, Kim, Kyong-Tai
Published 2014

A systematic assessment of mycobacterial F1-ATPase subunit ϵ’s role in latent ATPase hydrolysis

by Wong, Chui-Fann, Lau, Aik-Meng, Harikishore, Amaravadhi, Saw, Wuan-Geok, Shin, Joon, Ragunathan, Priya, Bhushan, Shashi, Ngan, So-Fong Cam, Sze, Siu Kwan, Bates, Roderick Wayland, Dick, Thomas, Grüber, Gerhard
Published 2021

Suprafenacine, an indazole-hydrazide agent, targets cancer cells through microtubule destabilization

by Choi, Bo-Hwa, Chattopadhaya, Souvik, Feng, Lin, Nguyen, Quoc Toan, Lim, Chuan Bian, Harikishore, Amaravadhi, Nanga, Ravi Prakash Reddy, Bharatham, Nagakumar, Zhao, Yan, Yoon, Ho Sup, Thanh, Le Nguyen, Liu, Xuewei
Published 2014

Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells

by Kim, Seong-Hoon, Ryu, Hye Guk, Lee, Juhyun, Shin, Joon, Harikishore, Amaravadhi, Jung, Hoe-Youn, Kim, Ye Seul, Lyu, Ha-Na, Oh, Eunji, Baek, Nam-In, Choi, Kwan-Yong, Yoon, Ho Sup, Kim, Kyong-Tai
Published 2015

Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis

by Saw, Wuan-Geok, Wu, Mu-Lu, Ragunathan, Priya, Biuković, Goran, Lau, Aik-Meng, Shin, Joon, Harikishore, Amaravadhi, Cheung, Chen-Yi, Hards, Kiel, Sarathy, Jickky Palmae, Bates, Roderick Wayland, Cook, Gregory M., Dick, Thomas, Grüber, Gerhard
Published 2020