Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents

Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents

Tuberculosis (TB) remains a leading cause of infectious disease-related mortality and morbidity. Pyrazinamide (PZA) is a critical component of the first-line TB treatment regimen because of its sterilizing activity against non-replicating Mycobacterium tuberculosis (Mtb), but its mechanism of action...

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Bibliographic Details
Main Authors: Hegde, Pooja V., Aragaw, Wassihun W., Cole, Malcolm S., Jachak, Gorakhnath, Ragunathan, Priya, Sharma, Sachin, Harikishore, Amaravadhi, Grüber, Gerhard, Dick, Thomas, Aldrich, Courtney C.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2023
Subjects:
Science::Biological sciences
Tuberculosis
Pyrazinoic Acid
Online Access:https://hdl.handle.net/10356/164677
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/164677

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