Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents

• المؤلفون الرئيسيون: Hegde, Pooja V., Aragaw, Wassihun W., Cole, Malcolm S., Jachak, Gorakhnath, Ragunathan, Priya, Sharma, Sachin, Harikishore, Amaravadhi, Grüber, Gerhard, Dick, Thomas, Aldrich, Courtney C.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Biological sciences; Tuberculosis; Pyrazinoic Acid
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/164677

Tuberculosis (TB) remains a leading cause of infectious disease-related mortality and morbidity. Pyrazinamide (PZA) is a critical component of the first-line TB treatment regimen because of its sterilizing activity against non-replicating Mycobacterium tuberculosis (Mtb), but its mechanism of action...