Structural and mechanistic insights into Mycobacterium abscessus as-partate decarboxylase PanD and a pyrazinoic acid-derived inhibitor

Structural and mechanistic insights into Mycobacterium abscessus as-partate decarboxylase PanD and a pyrazinoic acid-derived inhibitor

Mycobacterium tuberculosis (Mtb) aspartate decarboxylase PanD is required for biosynthesis of the essential cofactor coenzyme A and targeted by the first line drug pyrazinamide (PZA). PZA is a prodrug that is converted by a bacterial amidase into its bioactive form pyrazinoic acid (POA). Employing s...

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Bibliographic Details
Main Authors: Saw, Wuan Geok, Leow, Chen Yen, Harikishore, Amaravadhi, Shin, Joon, Cole, Malcolm S., Aragaw, Wassihun Wedajo, Ragunathan, Priya, Hegde, Pooja, Aldrich, Courtney C., Dick, Thomas, Grüber, Gerhard
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences::Biochemistry
Science::Biological sciences::Biophysics
Non-Tuberculous Mycobacteria
Mycobacterium Abscessus
Pyrazinamide
Pyrazinoic Acid
Coenzyme A
Aspartate Decarboxylase
Online Access:https://hdl.handle.net/10356/163126
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/163126

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