Therapeutic potential of promiscuous targets in Mycobacterium tuberculosis

by Lee, Bei Shi, Pethe, Kevin
Published 2020

Telacebec : an investigational antibacterial for the treatment of tuberculosis (TB)

by Lee, Bei Shi, Pethe, Kevin
Published 2022

Contribution of high-content imaging technologies to the development of anti-infective drugs

by Ang, Michelle Lay Teng, Pethe, Kevin
Published 2017

Targeting the cytochrome oxidases for drug development in mycobacteria

by Lee, Bei Shi, Sviriaeva, Ekaterina, Pethe, Kevin
Published 2020

Inhibiting respiration as a novel antibiotic strategy

by Lee, Bei Shi, Singh, Samsher, Pethe, Kevin
Published 2023

Chemical basis of combination therapy to combat antibiotic resistance

by Si, Zhangyong, Pethe, Kevin, Chan-Park, Mary B.
Published 2023

Oxidative phosphorylation — an update on a new, essential target space for drug discovery in mycobacterium tuberculosis

by Foo, Caroline Shi-Yan, Pethe, Kevin, Lupien, Andréanne
Published 2020

Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery

by Harikishore, Amaravadhi, Mathiyazakan, Vikneswaran, Pethe, Kevin, Grüber, Gerhard
Published 2023

The Qcrb inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus

by Sorayah, Ria, Moraski, Garret C., Barkan, Daniel, Pethe, Kevin
Published 2022

Features and functional importance of key residues of the Mycobacterium tuberculosis cytochrome bd oxidase

by Sviriaeva, Ekaterina, Manimekalai, Malathy Sony Subramanian, Grüber, Gerhard, Pethe, Kevin
Published 2021

Sensitivity of mycobacterium leprae to telacebec

by Lahiri, Ramanuj, Adams, Linda B., Thomas, Sangeeta Susan, Pethe, Kevin
Published 2022

Cryo-electron microscopy structure of the Mycobacterium tuberculosis cytochrome bcc:aa₃ supercomplex and a novel inhibitor targeting subunit cytochrome cI

by Mathiyazakan, Vikneswaran, Wong, Chui Fann, Harikishore, Amaravadhi, Pethe, Kevin, Grüber, Gerhard
Published 2023

Telacebec (Q203)-containing intermittent oral regimens sterilized mice infected with Mycobacterium ulcerans after only 16 doses

by Chauffour, Aurélie, Robert, Jérôme, Veziris, Nicolas, Aubry, Alexandra, Pethe, Kevin, Jarlier, Vincent
Published 2021

Toward a single-dose cure for buruli ulcer

by Thomas, Sangeeta Susan, Kalia, Nitin Pal, Ruf, Marie-Thérèse, Pluschke, Gerd, Pethe, Kevin
Published 2021

Cationic glycosylated block co-β-peptide acts on the cell wall of Gram-positive bacteria as anti-biofilm agents

by Zhang, Kaixi, Raju, Cheerlavancha, Zhong, Wenbin, Pethe, Kevin, Gründling, Angelika, Chan-Park, Mary B.
Published 2021

Bedaquiline Inhibits the ATP Synthase in Mycobacterium abscessus and Is Effective in Infected Zebrafish

by Dupont, Christian, Viljoen, Albertus, Thomas, Sangeeta, Roquet-Banères, Françoise, Herrmann, Jean-Louis, Pethe, Kevin, Kremer, Laurent
Published 2018

Isolation and characterization of a hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis cytochrome bcc and Mycobacterium smegmatis cytochrome aa3

by Berry, Edward A., Huang, Li-Shar, Kim, Mi-Sun, Jang, Jichan, Pethe, Kevin, Nurlilah AB Rahman
Published 2018

Naturally-occurring polymorphisms in QcrB are responsible for resistance to Telacebec in Mycobacterium abscessus

by Sorayah, Ria, Manimekalai, Malathy Sony Subramanian, Shin, Sung Jae, Koh, Won-Jung, Grüber, Gerhard, Pethe, Kevin
Published 2021

Inhibitors of energy metabolism interfere with antibiotic-induced death in mycobacteria

by Lee, Bei Shi, Kalia, Nitin Pal, Jin, Xin Er F., Hasenoehrl, Erik J., Berney, Michael, Pethe, Kevin
Published 2019

Carbon metabolism modulates the efficacy of drugs targeting the cytochrome bc1:aa3 in Mycobacterium tuberculosis

by Moraski, Garrett C., Miller, Marvin J., Pethe, Kevin, Kalia, Nitin Pal, Lee, Bei Shi, Nurlilah Ab Rahman
Published 2019