Inhibitors of energy metabolism interfere with antibiotic-induced death in mycobacteria

Energy metabolism has recently gained interest as a target space for antibiotic drug development in mycobacteria. Of particular importance is bedaquiline (Sirturo), which kills mycobacteria by inhibiting the F1F0 ATP synthase. Other components of the electron transport chain such as the NADH dehydro...

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Bibliographic Details
Main Authors: Lee, Bei Shi, Kalia, Nitin Pal, Jin, Xin Er F., Hasenoehrl, Erik J., Berney, Michael, Pethe, Kevin
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2019
Subjects:
ATP
Online Access:https://hdl.handle.net/10356/103762
http://hdl.handle.net/10220/48892
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Institution: Nanyang Technological University
Language: English