Inhibitors of energy metabolism interfere with antibiotic-induced death in mycobacteria

• Main Authors: Lee, Bei Shi, Kalia, Nitin Pal, Jin, Xin Er F., Hasenoehrl, Erik J., Berney, Michael, Pethe, Kevin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Medicine; ATP; Cell Death
• Online Access: https://hdl.handle.net/10356/103762; http://hdl.handle.net/10220/48892
• Institution: Nanyang Technological University

Energy metabolism has recently gained interest as a target space for antibiotic drug development in mycobacteria. Of particular importance is bedaquiline (Sirturo), which kills mycobacteria by inhibiting the F1F0 ATP synthase. Other components of the electron transport chain such as the NADH dehydro...