Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against Mycobacterium tuberculosis

بواسطة Fridianto, Kevin T, Li, Ming, Hards, Kiel, Negatu, Dereje A, Cook, Gregory M, Dick, Thomas, Lam, Yulin, Go, Mei-Lin
منشور في 2023

M. tuberculosis relies on trace oxygen to maintain energy homeostasis and survive in hypoxic environments

بواسطة Kalia, Nitin Pal, Singh, Samsher, Hards, Kiel, Cheung, Chen-Yi, Sviriaeva, Ekaterina, Banaei-Esfahani, Amir, Aebersold, Ruedi, Berney, Michael, Cook, Gregory M., Pethe, Kevin
منشور في 2023

Oxidative phosphorylation as a target space for tuberculosis: success, caution, and future directions

بواسطة Cook, Gregory M., Hards, Kiel, Dunn, Elyse, Heikal, Adam, Nakatani, Yoshio, Greening, Chris, Crick, Dean C., Fontes, Fabio L., Pethe, Kevin, Hasenoehrl, Erik, Berney, Michael
منشور في 2018

Antituberculosis activity of the antimalaria cytochrome bcc oxidase inhibitor SCR0911

بواسطة Chong, Sherilyn Shi Min, Manimekalai, Malathy Sony Subramanian, Sarathy, Jickky Palmae, Williams, Zoe C., Harold, Liam K., Cook, Gregory M., Dick, Thomas, Pethe, Kevin, Bates, Roderick Wayland, Grüber, Gerhard
منشور في 2020

Genomic profiling of mycobacterium tuberculosis strains, Myanmar

بواسطة Aung, Htin Lin, Nyunt, Wint Wint, Fong, Yang, Biggs, Patrick J., Winkworth, Richard C., Lockhart, Peter J., Yeo, Tsin Wen, Hill, Philip C., Cook, Gregory M., Aung, Si Thu
منشور في 2022

Extended blood stage sensitivity profiles of Plasmodium cynomolgi to doxycycline and tafenoquine, as a model for Plasmodium vivax

بواسطة Christensen, Peter, Cinzah, Rosy, Suwanarusk, Rossarin, Chua, Adeline Chiew Yen, Kaneko, Osamu, Kyle, Dennis E., Aung, Htin Lin, Matheson, Jessica, Bifani, Pablo, Rénia, Laurent, Cook, Gregory M., Snounou, Georges, Russell, Bruce
منشور في 2024

Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection

بواسطة Hasenoehrl, Erik J., Koh, Vanessa H., Ang, Michelle L. T., Sajorda, Dannah R., Hards, Kiel, Grüber, Gerhard, Alonso, Sylvie, Cook, Gregory M., Berney, Michael, Pethe, Kevin, Kalia, Nitin Pal, Ab Rahman, Nurlilah Binte
منشور في 2017

Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis

بواسطة Saw, Wuan-Geok, Wu, Mu-Lu, Ragunathan, Priya, Biuković, Goran, Lau, Aik-Meng, Shin, Joon, Harikishore, Amaravadhi, Cheung, Chen-Yi, Hards, Kiel, Sarathy, Jickky Palmae, Bates, Roderick Wayland, Cook, Gregory M., Dick, Thomas, Grüber, Gerhard
منشور في 2020

Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis

بواسطة Lee, Bei Shi, Hards, Kiel, Engelhart, Curtis A., Hasenoehrl, Erik J., Kalia, Nitin Pal, Mackenzie, Jared S., Sviriaeva, Ekaterina, Chong, Sherilyn Shi Min, Manimekalai, Malathy Sony S., Koh, Vanessa H., Chan, John, Xu, Jiayong, Alonso, Sylvie, Miller, Marvin J., Steyn, Adrie J. C., Grüber, Gerhard, Schnappinger, Dirk, Berney, Michael, Cook, Gregory M., Moraski, Garrett C., Pethe, Kevin
منشور في 2021

Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis

بواسطة Lee, Bei Shi, Hards, Kiel, Engelhart, Curtis A., Hasenoehrl, Erik J., Kalia, Nitin P., Mackenzie, Jared S., Sviriaeva, Ekaterina, Chong, Shi Min Sherilyn, Manimekalai, Malathy Sony S., Koh, Vanessa H., Chan, John, Xu, Jiayong, Alonso, Sylvie, Miller, Marvin J., Steyn, Adrie J. C., Grüber, G., Schnappinger, Dirk, Berney, Michael, Cook, Gregory M., Moraski, Garrett C., Pethe, Kevin
منشور في 2022