Deletion of a unique loop in the mycobacterial F-ATP synthase γ subunit sheds light on its inhibitory role in ATP hydrolysis-driven H+ pumping

• المؤلفون الرئيسيون: Hotra, Adam, Suter, Manuel, Biuković, Goran, Priya, Ragunathan, Kundu, Subhashri, Dick, Thomas, Grüber, Gerhard
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: Bioenergetics; FATP synthase
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/83414; http://hdl.handle.net/10220/41395
• المؤسسة: Nanyang Technological University

The F1FO-ATP synthase is one of the enzymes that is essential to meet the energy requirement of both the proliferating aerobic and hypoxic dormant stages of the life cycle of mycobacteria. Most F-ATP synthases consume ATP in the α3:β3 headpiece to drive the γ subunit, which couples ATP cleavage with...