Deletion of a unique loop in the mycobacterial F-ATP synthase γ subunit sheds light on its inhibitory role in ATP hydrolysis-driven H+ pumping
The F1FO-ATP synthase is one of the enzymes that is essential to meet the energy requirement of both the proliferating aerobic and hypoxic dormant stages of the life cycle of mycobacteria. Most F-ATP synthases consume ATP in the α3:β3 headpiece to drive the γ subunit, which couples ATP cleavage with...
Saved in:
Main Authors: | Hotra, Adam, Suter, Manuel, Biuković, Goran, Priya, Ragunathan, Kundu, Subhashri, Dick, Thomas, Grüber, Gerhard |
---|---|
Other Authors: | School of Biological Sciences |
Format: | Article |
Language: | English |
Published: |
2016
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/83414 http://hdl.handle.net/10220/41395 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
Similar Items
-
The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptation
by: Ragunathan, Priya, et al.
Published: (2018) -
Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase
by: Kundu, Subhashri, et al.
Published: (2017) -
Structural elements involved in ATP hydrolysis inhibition and ATP synthesis of tuberculosis and non-tuberculous mycobacterial F-ATP synthase decipher new targets for inhibitors
by: Wong, Chui Fann, et al.
Published: (2022) -
Unique structural and mechanistic properties of mycobacterial F-ATP synthases : implications for drug design
by: Kamariah, Neelagandan, et al.
Published: (2020) -
Power Stroke Angular Velocity Profiles of Archaeal A-ATP Synthase Versus Thermophilic and Mesophilic F-ATP Synthase Molecular Motors
by: Sielaff, Hendrik, et al.
Published: (2017)