Unique structural and mechanistic properties of mycobacterial F-ATP synthases : implications for drug design

• Main Authors: Kamariah, Neelagandan, Ragunathan, Priya, Shin, Joon, Saw, Wuan-Geok, Wong, Chui-Fann, Dick, Thomas, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences::Biochemistry; Science::Biological sciences::Molecular biology; F-ATP Synthase; Bioenergetics
• Online Access: https://hdl.handle.net/10356/138547
• Institution: Nanyang Technological University

The causative agent of Tuberculosis (TB) Mycobacterium tuberculosis (Mtb) encounters unfavourable environmental conditions in the lungs, including nutrient limitation, low oxygen tensions and/or low/high pH values. These harsh conditions in the host triggers Mtb to enter a dormant state in which the...