GaMF1.39’s antibiotic efficacy and its enhanced antitubercular activity in combination with Clofazimine, Telacebec, ND-011992 or TBAJ-876

GaMF1.39’s antibiotic efficacy and its enhanced antitubercular activity in combination with Clofazimine, Telacebec, ND-011992 or TBAJ-876

The Mycobacterium tuberculosis (Mtb) F-ATP synthase generates most of the biological energy currency ATP. Previously, we identified the mycobacterium-specific loop of the F-ATP synthase subunit γ as a new anti-tuberculosis target, discovered the novel diaminopyrimidine GaMF1,whose potency was improv...

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Bibliographic Details
Main Authors: Ragunathan, Priya, Ng, Pearly Shuyi, Singh, Samsher, Poh, Wee Han, Litty, Dennis, Kalia, Nitin Pal, Larsson, Simon, Harikishore, Amaravadhi, Rice, Scott A., Ingham, Philip William, Müller, Volker, Moraski, Garrett, Miller, Marvin J., Dick, Thomas, Pethe, Kevin, Grüber, Gerhard
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2023
Subjects:
Science::Biological sciences::Biochemistry
Bioenergetics
Mycobacterium Tuberculosis
Tuberculosis
F-ATP Synthase
Oxidative Phosphorylation
Aanti-TB Compound
Online Access:https://hdl.handle.net/10356/172412
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/172412

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