GaMF1.39’s antibiotic efficacy and its enhanced antitubercular activity in combination with Clofazimine, Telacebec, ND-011992 or TBAJ-876

• Main Authors: Ragunathan, Priya, Ng, Pearly Shuyi, Singh, Samsher, Poh, Wee Han, Litty, Dennis, Kalia, Nitin Pal, Larsson, Simon, Harikishore, Amaravadhi, Rice, Scott A., Ingham, Philip William, Müller, Volker, Moraski, Garrett, Miller, Marvin J., Dick, Thomas, Pethe, Kevin, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences::Biochemistry; Bioenergetics; Mycobacterium Tuberculosis; Tuberculosis; F-ATP Synthase; Oxidative Phosphorylation; Aanti-TB Compound
• Online Access: https://hdl.handle.net/10356/172412
• Institution: Nanyang Technological University

The Mycobacterium tuberculosis (Mtb) F-ATP synthase generates most of the biological energy currency ATP. Previously, we identified the mycobacterium-specific loop of the F-ATP synthase subunit γ as a new anti-tuberculosis target, discovered the novel diaminopyrimidine GaMF1,whose potency was improv...